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KMID : 0525720110160040282
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Journal of Chitin and Chitosan
2011 Volume.16 No. 4 p.282 ~ p.288
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Fabrication and Characterization of Electrospun CS (core)/PLA (shell) Nanofibers
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Nguyen Thuy Thi Thu
Park Jun-Seo
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Abstract
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In order to develop a composite material for use in drug delivery, a coaxial electrospinning technique was used to simultaneously electrospin two different polymer solutions into core/shell structured nanofibers in which chitosan (CS) and poly (lactic acid) (PLA) formed the core and shell layers, respectively. The core/shell structure of the electrospun CS/PLA nanofibers was determined by contact angle measurements, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy. The results of the measurements indicated that the flow rates of the core and shell and the applied voltage strongly affected the stability of the structure of core/shell nanofibers. The optimal processing conditions for the fabrication of the complete core/shell structure of CS/PLA nanofibers were as follows: a core feed rate less than 0.1 mL/h, a shell feed rate of 0.5 mL/h, distance of 14 cm between the needle and the collector, and an applied voltage of 12 kV. A fine morphology of smooth core/shell structured nanofibers was observed by field-emission scanning electron microscopy images. A tensile test indicated that a non-woven mat of core/shell structured nanofibers had high mechanical strength.
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KEYWORD
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core/shell structured nanofibers, chitosan, poly (lactic acid)
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